Annandale and Eskdale is a committee area in Dumfries and Galloway, Scotland. It covers the areas of Annandale and Eskdale, the straths of the River Annan and the River Esk respectively.
It was formerly (1975-96) a local government district in the Dumfries and Galloway region of Scotland. In 1996 it was included in the Dumfries and Galloway council area.